KB ID 0001447

Problem

If your Exchange 2010 Server Stops working after a 6 to 12 hour window, then this is a known problem caused by last months (July 2018) security updates. You will also notice that the ‘transport service‘ becomes unresponsive.

Note: A reboot will temporarily fix the problem but the server then ceases to function after the same time.

Solution

Which update you need to uninstall, depends on your operating system (2008/2012)

Server 2008 R2

KB4338423 and KB4338823 
or
KB4338818 

Server 2012

KB4338820 
or
KB4338830 

Server 2012 R2

KB4338824 
or
KB4338815 

Microsofts Response: 

Related Articles, References, Credits, or External Links

NA